Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50317907
Substrate
n/a
Meas. Tech.
ChEMBL_630197 (CHEMBL1117300)
Ki
4400±n/a nM
Citation
 Asada, MObitsu, TKinoshita, ANagase, TYoshida, TYamaura, YTakizawa, HYoshikawa, KSato, KNarita, MNakai, HToda, MTobe, Y 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs. Bioorg Med Chem 18:3212-23 (2010) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_MOUSE | PGE receptor, EP1 subtype | Prostaglandin E1 | Prostaglandin E2 receptor EP1 subtype | Prostanoid EP1 receptor | Ptger1 | Ptgerep1
Type:
G-protein coupled receptor
Mol. Mass.:
43000.62
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
405
Sequence:
MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL
  
Inhibitor
Name:
BDBM50317907
Synonyms:
3-[4-[(3-Chlorophenoxy)methyl]-2-({[(1R)-1-(3,5-dimethylphenyl)-3-methylbutyl]amino}carbonyl)phenyl]propanoicacid | CHEMBL1094156
Type:
Small organic molecule
Emp. Form.:
C30H34ClNO4
Mol. Mass.:
508.048
SMILES:
CC(C)C[C@@H](NC(=O)c1cc(COc2cccc(Cl)c2)ccc1CCC(O)=O)c1cc(C)cc(C)c1 |r|
Structure:
Search PDB for entries with ligand similarity: