Reaction Details Report a problem with these data
Target
P2Y purinoceptor 4
Ligand
BDBM50319130
Substrate
n/a
Meas. Tech.
ChEMBL_635652 (CHEMBL1119544)
EC50
560±n/a nM
Citation
 Maruoka, H; Barrett, MO; Ko, H; Tosh, DK; Melman, A; Burianek, LE; Balasubramanian, R; Berk, B; Costanzi, S; Harden, TK; Jacobson, KA Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. J Med Chem 53:4488-501 (2010) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 4
Synonyms:
P2P | P2Y purinoceptor 4 | P2Y4 | UNR | Uridine nucleotide receptor | P2RY4_HUMAN | P2RY4 | NRU | Pyrimidinergic receptor P2Y4
Type:
PROTEIN
Mol. Mass.:
40977.17
Organism:
Human
Description:
ChEMBL_751027
Residue:
365
Sequence:
MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL
  
Inhibitor
Name:
BDBM50319130
Synonyms:
((((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(methoxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methylphosphonic(((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-(methoxyamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl phosphoric)anhydride | CHEMBL1083257
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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