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Target
C-X-C chemokine receptor type 3
Ligand
BDBM50320127
Substrate
n/a
Meas. Tech.
ChEMBL_635393 (CHEMBL1120064)
IC50
538±n/a nM
Citation
 Crosignani, S; Missotten, M; Cleva, C; Dondi, R; Ratinaud, Y; Humbert, Y; Mandal, AB; Bombrun, A; Power, C; Chollet, A; Proudfoot, A Discovery of a novel series of CXCR3 antagonists. Bioorg Med Chem Lett 20:3614-7 (2010) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
C-X-C chemokine receptor type 3 (CXCR3) | CXCR3A | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3A) | AAO92295.1 | chemokine (C-X-C motif) receptor 3 | CXCR3_HUMAN | CXCR3 | GPR9
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Human
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
  
Inhibitor
Name:
BDBM50320127
Synonyms:
N-(3-(1-(2-(4-((N-benzyl-4-chlorophenylsulfonamido)methyl)benzoyl)hydrazinyl)ethyl)phenyl)acetamide | CHEMBL1085565
Type:
Small organic molecule
Emp. Form.:
C31 H29 Cl N4 O4 S
Mol. Mass.:
589.10435
SMILES:
CC(=O)Nc1cccc(c1)C(C)=NNC(=O)c1ccc(CN(Cc2ccccc2)S(=O)(=O)c2ccc(Cl)cc2)cc1 |w:12.13|
Structure:
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