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Target
Sodium- and chloride-dependent GABA transporter 3
Ligand
BDBM90787
Substrate
n/a
Meas. Tech.
ChEMBL_638000 (CHEMBL1166721)
IC50
110000±n/a nM
Citation
 Faust, MR; Höfner, G; Pabel, J; Wanner, KT Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship. Eur J Med Chem 45:2453-66 (2010) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 3
Synonyms:
GAT-3 | Solute carrier family 6 member 11 | S6A11_HUMAN | SLC6A11 | GABT3 | GAT3 | GABA transporter 3
Type:
PROTEIN
Mol. Mass.:
70607.60
Organism:
Human
Description:
ChEMBL_1454198
Residue:
632
Sequence:
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
  
Inhibitor
Name:
BDBM90787
Synonyms:
SMR000326834 | cid_11957555 | GUVACINE | MLS000859975 | Guvacine hydrochloride | 1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C6H9NO2
Mol. Mass.:
127.06
SMILES:
OC(=O)C1=CCCNC1 |t:3|
Structure:
Search PDB for entries with ligand similarity: