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Target
Histone deacetylase 1
Ligand
BDBM50320762
Substrate
n/a
Meas. Tech.
ChEMBL_639141 (CHEMBL1167402)
IC50
700±n/a nM
Citation
 Kiyokawa, S; Hirata, Y; Nagaoka, Y; Shibano, M; Taniguchi, M; Yasuda, M; Baba, K; Uesato, S New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group. Bioorg Med Chem 18:3925-33 (2010) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50320762
Synonyms:
CHEMBL1164063 | N-(2-Aminophenyl)-4-(((biphenyl-4-ylmethyl)(2-hydroxyethyl)amino)ethyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C29H29N3O2
Mol. Mass.:
451.5595
SMILES:
Nc1ccccc1NC(=O)c1ccc(CN(CCO)Cc2ccc(cc2)-c2ccccc2)cc1
Structure:
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