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Target
KiSS-1 receptor
Ligand
BDBM50320807
Substrate
n/a
Meas. Tech.
ChEMBL_639178 (CHEMBL1167874)
IC50
890±n/a nM
Citation
 Kobayashi, T; Sasaki, S; Tomita, N; Fukui, S; Kuroda, N; Nakayama, M; Kiba, A; Takatsu, Y; Ohtaki, T; Itoh, F; Baba, A Synthesis and structure-activity relationships of 2-acylamino-4,6-diphenylpyridine derivatives as novel antagonists of GPR54. Bioorg Med Chem 18:3841-59 (2010) [PubMed]  Article 
Target
Name:
KiSS-1 receptor
Synonyms:
AXOR12 | G-protein Coupled Receptor 54 | G-protein coupled receptor 54 (GPR54) | GPR54 | Hypogonadotropin-1 | KISS1R | KISSR_HUMAN | KiSS-1R | Kisspeptins receptor | Metastin receptor | hOT7T175
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42613.79
Organism:
Homo sapiens (Human)
Description:
Binding assay was performed using membranes from the CHO cell transfectants.
Residue:
398
Sequence:
MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
  
Inhibitor
Name:
BDBM50320807
Synonyms:
CHEMBL1165431 | N-{4-[3-(beta-Alanylamino)phenyl]-6-(2-aminophenyl)-3-cyanopyridin-2-yl}benzamide
Type:
Small organic molecule
Emp. Form.:
C28H24N6O2
Mol. Mass.:
476.5292
SMILES:
NCCC(=O)Nc1cccc(c1)-c1cc(nc(NC(=O)c2ccccc2)c1C#N)-c1ccccc1N
Structure:
Search PDB for entries with ligand similarity: