Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50323003
Substrate
n/a
Meas. Tech.
ChEMBL_643523 (CHEMBL1212387)
IC50
0.4±n/a nM
Citation
 Hortala, L; Rinaldi-Carmona, M; Congy, C; Boulu, L; Sadoun, F; Fabre, G; Finance, O; Barth, F Rational design of a novel peripherally-restricted, orally active CB(1) cannabinoid antagonist containing a 2,3-diarylpyrrole motif. Bioorg Med Chem Lett 20:4573-7 (2010) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50323003
Synonyms:
1'-(5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-(2-(methylsulfonyl)ethyl)-1H-pyrrole-2-carbonyl)-1,4'-bipiperidine-4'-carboxamide | CHEMBL1210779
Type:
Small organic molecule
Emp. Form.:
C31H35Cl3N4O4S
Mol. Mass.:
666.058
SMILES:
CS(=O)(=O)CCn1c(cc(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)N1CCC(CC1)(N1CCCCC1)C(N)=O
Structure:
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