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Target
P-selectin glycoprotein ligand 1
Ligand
BDBM50324664
Substrate
n/a
Meas. Tech.
ChEMBL_649756 (CHEMBL1219454)
IC50
250000±n/a nM
Citation
 Huang, A; Moretto, A; Janz, K; Lowe, M; Bedard, PW; Tam, S; Di, L; Clerin, V; Sushkova, N; Tchernychev, B; Tsao, DH; Keith, JC; Shaw, GD; Schaub, RG; Wang, Q; Kaila, N Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury. J Med Chem 53:6003-17 (2010) [PubMed]  Article 
Target
Name:
P-selectin glycoprotein ligand 1
Synonyms:
P-selectin glycoprotein ligand 1 | P-selectin/P-selectin glycoprotein ligand 1 | SELPLG | SELPL_HUMAN
Type:
PROTEIN
Mol. Mass.:
43174.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_649756
Residue:
412
Sequence:
MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
  
Inhibitor
Name:
BDBM50324664
Synonyms:
3-Hydroxy-2-(1-phenylcyclopropyl)-7,8,9,10-tetrahydrobenzo-[h]quinoline-4-carboxylic Acid | CHEMBL1215806
Type:
Small organic molecule
Emp. Form.:
C23H21NO3
Mol. Mass.:
359.4177
SMILES:
OC(=O)c1c(O)c(nc2c3CCCCc3ccc12)C1(CC1)c1ccccc1
Structure:
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