Reaction Details Report a problem with these data
Target
Cell division control protein 42 homolog
Ligand
BDBM50324672
Substrate
n/a
Meas. Tech.
ChEMBL_652970 (CHEMBL1226173)
IC50
9000±n/a nM
Citation
 Pelish, HE; Peterson, JR; Salvarezza, SB; Rodriguez-Boulan, E; Chen, JL; Stamnes, M; Macia, E; Feng, Y; Shair, MD; Kirchhausen, T Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol 2:39-46 (2006) [PubMed]  Article 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM50324672
Synonyms:
CHEMBL1222038 | Secramine A
Type:
Small organic molecule
Emp. Form.:
C35H39BrN2O5S
Mol. Mass.:
679.664
SMILES:
COc1ccc(CS[C@@H]2C\C(C[C@H]3Oc4c5c(CN[C@H](CO)C[C@]235)cc(OCC2CC2)c4Br)=N\OCc2ccccc2)cc1 |r|
Structure:
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