Reaction Details Report a problem with these data
Target
Solute carrier family 2, facilitated glucose transporter member 1
Ligand
BDBM50326284
Substrate
n/a
Meas. Tech.
ChEMBL_659928 (CHEMBL1247186)
IC50
>10000±n/a nM
Citation
Nomura, S; Sakamaki, S; Hongu, M; Kawanishi, E; Koga, Y; Sakamoto, T; Yamamoto, Y; Ueta, K; Kimata, H; Nakayama, K; Tsuda-Tsukimoto, M Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. J Med Chem 53:6355-60 (2010) [PubMed] Article
More Info.:
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 1
Synonyms:
GTR1_RAT | Glut1 | Slc2a1
Type:
PROTEIN
Mol. Mass.:
53969.94
Organism:
Rattus norvegicus
Description:
ChEMBL_659928
Residue:
492
Sequence:
MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
Inhibitor
Name:
BDBM50326284
Synonyms:
1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene | CHEMBL1243275
Type:
Small organic molecule
Emp. Form.:
C24H25FO6S
Mol. Mass.:
460.515
SMILES:
Cc1cccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(s1)-c1ccc(F)cc1 |r|