Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50328535
Substrate
n/a
Meas. Tech.
ChEMBL_665680 (CHEMBL1261611)
IC50
114±n/a nM
Citation
 Zhou, CGarcia-Calvo, MPinto, SLombardo, MFeng, ZBender, KPryor, KDBhatt, URChabin, RMGeissler, WMShen, ZTong, XZhang, ZWong, KKRoy, RSChapman, KTYang, LXiong, Y Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity. J Med Chem 53:7251-63 (2010) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM50328535
Synonyms:
5,6-Dichloro-2-[(2S)-1-(2-methylalanyl-4-chloro-L-phenylalanyl)pyrrolidin-2-yl]-1H-benzimidazole | CHEMBL1259119
Type:
Small organic molecule
Emp. Form.:
C24H26Cl3N5O2
Mol. Mass.:
522.855
SMILES:
CC(C)(N)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 |r|
Structure:
Search PDB for entries with ligand similarity: