Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50328534
Substrate
n/a
Meas. Tech.
ChEMBL_665681 (CHEMBL1261612)
IC50
15±n/a nM
Citation
 Zhou, CGarcia-Calvo, MPinto, SLombardo, MFeng, ZBender, KPryor, KDBhatt, URChabin, RMGeissler, WMShen, ZTong, XZhang, ZWong, KKRoy, RSChapman, KTYang, LXiong, Y Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity. J Med Chem 53:7251-63 (2010) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
PCP_MOUSE | Prcp | Proline carboxypeptidase | Prolylcarboxypeptidase
Type:
PROTEIN
Mol. Mass.:
55028.96
Organism:
Mus musculus
Description:
ChEMBL_1335505
Residue:
491
Sequence:
MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGFADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLPAWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNIIFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMKKWILDFYSNIQ
  
Inhibitor
Name:
BDBM50328534
Synonyms:
2-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,6-dichloro-1Hbenzimidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}-2-methylpropanamide | CHEMBL1259118
Type:
Small organic molecule
Emp. Form.:
C30H31Cl2N5O2
Mol. Mass.:
564.505
SMILES:
CC(C)(N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 |r|
Structure:
Search PDB for entries with ligand similarity: