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Target
Heat shock protein HSP 90-beta
Ligand
BDBM20800
Substrate
n/a
Meas. Tech.
ChEMBL_675337 (CHEMBL1273374)
Kd
1.7±n/a nM
Citation
 Massey, AJ ATPases as drug targets: insights from heat shock proteins 70 and 90. J Med Chem 53:7280-6 (2010) [PubMed]  Article 
Target
Name:
Heat shock protein HSP 90-beta
Synonyms:
HSP 84 | HSP 90 | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) | HS90B_HUMAN | HSP90AB1 | HSP90B | HSPC2 | HSPCB
Type:
Molecular Chaperone
Mol. Mass.:
83229.45
Organism:
Human
Description:
P08238
Residue:
724
Sequence:
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
  
Inhibitor
Name:
BDBM20800
Synonyms:
CHEMBL467399 | 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine | 2-amino-6-halopurine analogue, 20 | hsp90_107
Type:
Small organic molecule
Emp. Form.:
C14H15ClN6O
Mol. Mass.:
318.10
SMILES:
Cc1cnc(c(c1OC)C)Cn2cnc3c2nc(nc3Cl)N
Structure:
Search PDB for entries with ligand similarity: