Reaction Details Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50329412
Substrate
n/a
Meas. Tech.
ChEMBL_675650 (CHEMBL1274011)
Ki
0.93±n/a nM
Citation
 Lacivita, E; De Giorgio, P; Lee, IT; Rodeheaver, SI; Weiss, BA; Fracasso, C; Caccia, S; Berardi, F; Perrone, R; Zhang, MR; Maeda, J; Higuchi, M; Suhara, T; Schetz, JA; Leopoldo, M Design, synthesis, radiolabeling, and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential positron emission tomography tracer for the dopamine D(4) receptors. J Med Chem 53:7344-55 (2010) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(4) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.4 | DRD4_RAT | Dopamine receptor | Drd4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41307.65
Organism:
RAT
Description:
DOPAMINE D4.4 0 RAT::P30729
Residue:
387
Sequence:
MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
  
Inhibitor
Name:
BDBM50329412
Synonyms:
CHEMBL1270423 | N-[2-[4-(3-Cyanopyridin-2-yl)piperazin-1-yl]ethyl]-4-fluorobenzamide
Type:
Small organic molecule
Emp. Form.:
C19H20FN5O
Mol. Mass.:
353.3934
SMILES:
Fc1ccc(cc1)C(=O)NCCN1CCN(CC1)c1ncccc1C#N
Structure:
Search PDB for entries with ligand similarity: