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Target
Prostaglandin D2 receptor
Ligand
BDBM50331743
Substrate
n/a
Meas. Tech.
ChEMBL_687945 (CHEMBL1291617)
Ki
0.39±n/a nM
Citation
 Li, L; Beaulieu, C; Carriere, MC; Denis, D; Greig, G; Guay, D; O'Neill, G; Zamboni, R; Wang, Z Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore. Bioorg Med Chem Lett 20:7462-5 (2010) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor
Synonyms:
PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor
Type:
Enzyme
Mol. Mass.:
40288.87
Organism:
Homo sapiens (Human)
Description:
Q13258
Residue:
359
Sequence:
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
  
Inhibitor
Name:
BDBM50331743
Synonyms:
2-((R)-9-((R)-1-(4-chlorophenyl)-2,2-difluoroethyl)-6-fluoro-8-(methylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid | CHEMBL1290755
Type:
Small organic molecule
Emp. Form.:
C23H21ClF3NO4S
Mol. Mass.:
499.93
SMILES:
CS(=O)(=O)c1cc(F)cc2c3CCC[C@H](CC(O)=O)c3n([C@@H](C(F)F)c3ccc(Cl)cc3)c12 |r|
Structure:
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