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Target
Type-1 angiotensin II receptor
Ligand
BDBM50047126
Substrate
n/a
Meas. Tech.
ChEMBL_717323 (CHEMBL1669992)
Kd
0.0501±n/a nM
Citation
 Naik, P; Murumkar, P; Giridhar, R; Yadav, MR Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. Bioorg Med Chem 18:8418-56 (2010) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
Angiotensin II receptor | ANGIOTENSIN AT1 | AGTR1_RABIT | AGTR1 | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
Rabbit
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50047126
Synonyms:
2-Ethyl-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-5,6,7,8-tetrahydro-quinoline | ZD-6888 | 2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-5,6,7,8-tetrahydro-quinoline | CHEMBL418226
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCc1cc(OCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2CCCCc2n1
Structure:
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