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Target
Type-1 angiotensin II receptor
Ligand
BDBM50006909
Substrate
n/a
Meas. Tech.
ChEMBL_717412 (CHEMBL1670311)
Kd
0.0813±n/a nM
Citation
 Naik, P; Murumkar, P; Giridhar, R; Yadav, MR Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. Bioorg Med Chem 18:8418-56 (2010) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
Angiotensin II receptor | ANGIOTENSIN AT1 | AGTR1_RABIT | AGTR1 | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
Rabbit
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50006909
Synonyms:
2-Butyl-5-chloro-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid | E 3174 | 2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid (EXP3174) | 2-Butyl-5-chloro-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid (EXP3174) | EXP3174 | 2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid | CHEMBL907 | Carboxylic Acid Metabolite (E-3174)
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCCCc1nc(c(n1Cc2ccc(cc2)c3ccccc3c4[nH]nnn4)C(=O)O)Cl
Structure:
Search PDB for entries with ligand similarity: