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Target
Aldo-keto reductase family 1 member C3
Ligand
BDBM50227631
Substrate
n/a
Meas. Tech.
ChEMBL_728759 (CHEMBL1686172)
IC50
>50000±n/a nM
Citation
 Chiasson, JF; Boulet, L; Brideau, C; Chau, A; Claveau, D; Côté, B; Ethier, D; Giroux, A; Guay, J; Guiral, S; Mancini, J; Massé, F; Méthot, N; Riendeau, D; Roy, P; Rubin, J; Xu, D; Yu, H; Ducharme, Y; Friesen, RW Trisubstituted ureas as potent and selective mPGES-1 inhibitors. Bioorg Med Chem Lett 21:1488-92 (2011) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member C3
Synonyms:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | Dihydrodiol dehydrogenase type I | Estradiol 17-beta-dehydrogenase | Testosterone 17-beta-dehydrogenase 5 | Aldo-keto reductase family 1 member C3 | Aldo-keto reductase family 1 member C3 (AKR1C3) | Aldo-keto reductase family 1 member C3 (AK1C3) | Dihydrodiol dehydrogenase 3 | 3-alpha-HSD type 2 | Prostaglandin F synthase | Aldo-keto reductase family 1 member C3 (AK1C3a) | AK1C3_HUMAN | AKR1C3 | DDH1 | HSD17B5 | KIAA0119 | PGFS | Aldo-keto-reductase family 1 member C3 | 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3)
Type:
Enzyme
Mol. Mass.:
36859.86
Organism:
Human
Description:
P42330
Residue:
323
Sequence:
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSDEY
  
Inhibitor
Name:
BDBM50227631
Synonyms:
2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile | CHEMBL412099
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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