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Target
C-C chemokine receptor type 2
Ligand
BDBM50339631
Substrate
n/a
Meas. Tech.
ChEMBL_735000 (CHEMBL1693607)
IC50
>10000±n/a nM
Citation
 Laborde, E; Macsata, RW; Meng, F; Peterson, BT; Robinson, L; Schow, SR; Simon, RJ; Xu, H; Baba, K; Inagaki, H; Ishiwata, Y; Jomori, T; Matsumoto, Y; Miyachi, A; Nakamura, T; Okamoto, M; Handel, TM; Bernard, CC Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function. J Med Chem 54:1667-81 (2011) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50339631
Synonyms:
1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-phenylphenyl)urea | CHEMBL1688881
Type:
Small organic molecule
Emp. Form.:
C21H16N2O4
Mol. Mass.:
360.3627
SMILES:
O=C(NC(=O)c1ccc2OCOc2c1)Nc1cccc(c1)-c1ccccc1
Structure:
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