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Target
Mas-related G-protein coupled receptor member X1
Ligand
BDBM50340751
Substrate
n/a
Meas. Tech.
ChEMBL_740644 (CHEMBL1763646)
IC50
108±n/a nM
Citation
 Bayrakdarian, M; Butterworth, J; Hu, YJ; Santhakumar, V; Tomaszewski, MJ Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists. Bioorg Med Chem Lett 21:2102-5 (2011) [PubMed]  Article 
Target
Name:
Mas-related G-protein coupled receptor member X1
Synonyms:
MRGPRX1 | MRGX1 | MRGX1_HUMAN | SNSR3 | SNSR4
Type:
PROTEIN
Mol. Mass.:
36253.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_516621
Residue:
322
Sequence:
MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFITVAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASEVDEGGGQLPEEILELSGSRLEQ
  
Inhibitor
Name:
BDBM50340751
Synonyms:
CHEMBL1762705 | N-((3-bromopyridin-4-yl)methyl)-2-(4-(2-(4-chlorophenethylamino)pyrimidin-4-yl)piperazin-1-yl)-N-ethylacetamide
Type:
Small organic molecule
Emp. Form.:
C26H31BrClN7O
Mol. Mass.:
572.928
SMILES:
CCN(Cc1ccncc1Br)C(=O)CN1CCN(CC1)c1ccnc(NCCc2ccc(Cl)cc2)n1
Structure:
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