Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50344074
Substrate
n/a
Meas. Tech.
ChEMBL_748546
EC50
1568±n/a nM
Citation
 Walsh, SP; Severino, A; Zhou, C; He, J; Liang, GB; Tan, CP; Cao, J; Eiermann, GJ; Xu, L; Salituro, G; Howard, AD; Mills, SG; Yang, L 3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists. Bioorg Med Chem Lett 21:3390-4 (2011) [PubMed]  Article  BDB Entry
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50344074
Synonyms:
CHEMBL1777867 | rac-3-(4-(5-bromopyrimidin-2-yloxy)phenyl)hex-4-ynoic acid
Type:
Small organic molecule
Emp. Form.:
C16H13BrN2O3
Mol. Mass.:
361.19
SMILES:
CC#CC(CC(O)=O)c1ccc(Oc2ncc(Br)cn2)cc1
Structure:
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