Target
B1 bradykinin receptor
Ligand
BDBM50344087
Substrate
n/a
Meas. Tech.
ChEMBL_748611 (CHEMBL1780464)
Ki
0.17±n/a nM
Citation
 Chen, JJNguyen, TD'Amico, DCQian, WHuman, JAya, TBiswas, KFotsch, CHan, NLiu, QNishimura, NPeterkin, TAYang, KZhu, JRiahi, BBHungate, RWAndersen, NGColyer, JTFaul, MMKamassah, AWang, JJona, JKumar, GJohnson, EAskew, BC 3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation. Bioorg Med Chem Lett 21:3384-9 (2011) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50344087
Synonyms:
2-(1-(3,4-dichlorophenylsulfonyl)-3-oxopiperazin-2-yl)-N-((R)-6-(piperidin-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)acetamide | CHEMBL1777879
Type:
Small organic molecule
Emp. Form.:
C28H34Cl2N4O4S
Mol. Mass.:
593.565
SMILES:
Clc1ccc(cc1Cl)S(=O)(=O)N1CCNC(=O)C1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12 |r|
Structure:
Search PDB for entries with ligand similarity: