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Target
Prostaglandin D2 receptor 2
Ligand
BDBM50344991
Substrate
n/a
Meas. Tech.
ChEMBL_749146 (CHEMBL1780743)
IC50
1.3±n/a nM
Citation
 Luker, T; Bonnert, R; Schmidt, J; Sargent, C; Paine, SW; Thom, S; Pairaudeau, G; Patel, A; Mohammed, R; Akam, E; Dougall, I; Davis, AM; Abbott, P; Brough, S; Millichip, I; McInally, T Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids. Bioorg Med Chem Lett 21:3616-21 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
Crth2 | G protein-coupled receptor 44 | Gpr44 | PD2R2_RAT | Ptgdr2
Type:
PROTEIN
Mol. Mass.:
45345.57
Organism:
Rattus norvegicus
Description:
ChEMBL_749146
Residue:
403
Sequence:
MANITLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHRVCLMLWALAVLNTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLQLHHRGRQRTGRFVRLVAAIVVAFILCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVLTCPDMLHKLRRSLLTVLESVLVEDSDLSTGPGKRCRRRHRRRASSTTTPASTLLLADRFPQLRPARLIGWMRRGSAELPRRVREQSQEKQGSLSCTLD
  
Inhibitor
Name:
BDBM50344991
Synonyms:
2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl)biphenyl-2-yloxy)acetic acid | CHEMBL1778639
Type:
Small organic molecule
Emp. Form.:
C18H17F3O5S
Mol. Mass.:
402.385
SMILES:
CCS(=O)(=O)c1ccc(c(C)c1)-c1cc(ccc1OCC(O)=O)C(F)(F)F
Structure:
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