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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50345242
Substrate
n/a
Meas. Tech.
ChEMBL_752074 (CHEMBL1786238)
IC50
54±n/a nM
Citation
 Xiang, Y; Hirth, B; Asmussen, G; Biemann, HP; Bishop, KA; Good, A; Fitzgerald, M; Gladysheva, T; Jain, A; Jancsics, K; Liu, J; Metz, M; Papoulis, A; Skerlj, R; Stepp, JD; Wei, RR The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. Bioorg Med Chem Lett 21:3050-6 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM50345242
Synonyms:
CHEMBL1782513 | trans-5-(6-(4-aminocyclohexylamino)pyrazin-2-yl)benzofuran-2-carboxylic acid
Type:
Small organic molecule
Emp. Form.:
C19H20N4O3
Mol. Mass.:
352.3871
SMILES:
N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O |r,wU:4.7,wD:1.0,(18.96,-16.61,;20.29,-17.38,;20.29,-18.92,;21.63,-19.69,;22.95,-18.91,;22.95,-17.38,;21.62,-16.61,;24.29,-19.68,;25.62,-18.9,;25.61,-17.36,;26.94,-16.59,;28.28,-17.36,;28.27,-18.9,;26.95,-19.66,;29.6,-19.66,;29.6,-21.21,;30.93,-21.98,;32.27,-21.2,;33.74,-21.67,;34.64,-20.41,;33.72,-19.17,;32.26,-19.66,;30.93,-18.89,;36.18,-20.41,;36.95,-21.73,;36.94,-19.07,)|
Structure:
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