Reaction Details Report a problem with these data
Target
Chitinase
Ligand
BDBM50065988
Substrate
n/a
Meas. Tech.
ChEMBL_756521 (CHEMBL1804594)
IC50
12400±n/a nM
Citation
 Garner, AL; Gloeckner, C; Tricoche, N; Zakhari, JS; Samje, M; Cho-Ngwa, F; Lustigman, S; Janda, KD Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem 54:3963-72 (2011) [PubMed]  Article 
Target
Name:
Chitinase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
55694.80
Organism:
Onchocerca volvulus
Description:
ChEMBL_1369100
Residue:
497
Sequence:
MRIGAMLIPFIILGNAIIAYGYVRGCYYTNWAQYRQGEGKFLPEDIPKGLCTHILYAFAKVDQSGTSLPFEWNDEDTNWSKGMYSRVTKLKENDPEMKILLSYGGYNFGSSTFTAIRNRAEKRKHFIKSAIAFLRKNKFDGFDFDWEYPIGMAQEYAKLVNEMKVAFVEEAKKSDSEQLLLTAAVSAGKHTIDQSYNVQSLGENFDLLSLMSYDFHGSWEMNVDLHAKLHPTKGETSGTGIFNTEFAANYWLSKGMPKQKIIIGIPTYGRGWTLRDSSKTTIGAEGISPSSPSTTNPAGGTAAYWEICKYLKEGGKETIDEQGVGACMVQGSQWYGYDNEETIRMKMRWLKEKGYGGAFIWTLDFDDFKGTSCGEGPYPLLSAINHELKGEATATTRSLRTTITQSSTIGSTKFETTTTASEITKNNKIKTTTIAVEPTGESSDIKCPESFGLFRHPNDCHLFIHCAHDHPYVKLCPPNTFFNDKIKVCDHFGECDE
  
Inhibitor
Name:
BDBM50065988
Synonyms:
3,5-Dichloro-N-(4-chloro-phenyl)-2-hydroxy-benzamide | CHEMBL97945
Type:
Small organic molecule
Emp. Form.:
C13H8Cl3NO2
Mol. Mass.:
316.567
SMILES:
Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: