Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM50349174
Substrate
n/a
Meas. Tech.
ChEMBL_759674 (CHEMBL1811418)
IC50
70±n/a nM
Citation
 Lo, HY; Nemoto, PA; Kim, JM; Hao, MH; Qian, KC; Farrow, NA; Albaugh, DR; Fowler, DM; Schneiderman, RD; Michael August, E; Martin, L; Hill-Drzewi, M; Pullen, SS; Takahashi, H; De Lombaert, S Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region. Bioorg Med Chem Lett 21:4533-9 (2011) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | Mast cell protease I | Chymase precursor | CMA1_HUMAN | CMA1 | CYH | CYM
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Human
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50349174
Synonyms:
CHEMBL1807526
Type:
Small organic molecule
Emp. Form.:
C20H18N2O3S
Mol. Mass.:
n/a
SMILES:
Cc1cccc2scc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c12
Structure:
Search PDB for entries with ligand similarity: