Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM50349184
Substrate
n/a
Meas. Tech.
ChEMBL_759674 (CHEMBL1811418)
IC50
1900±n/a nM
Citation
 Lo, HY; Nemoto, PA; Kim, JM; Hao, MH; Qian, KC; Farrow, NA; Albaugh, DR; Fowler, DM; Schneiderman, RD; Michael August, E; Martin, L; Hill-Drzewi, M; Pullen, SS; Takahashi, H; De Lombaert, S Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region. Bioorg Med Chem Lett 21:4533-9 (2011) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Human
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50349184
Synonyms:
CHEMBL1807527
Type:
Small organic molecule
Emp. Form.:
C19H16N2O3S
Mol. Mass.:
352.407
SMILES:
OC(=O)CCn1c2ccccc2n(Cc2csc3ccccc23)c1=O
Structure:
Search PDB for entries with ligand similarity: