Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50350349
Substrate
n/a
Meas. Tech.
ChEMBL_761105 (CHEMBL1815359)
Ki
210±n/a nM
Citation
 Iwahashi, M; Shimabukuro, A; Onoda, T; Matsunaga, Y; Okada, Y; Matsumoto, R; Nambu, F; Nakai, H; Toda, M Discovery of selective indole-based prostaglandin D2 receptor antagonist. Bioorg Med Chem 19:4574-88 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_MOUSE | PGE receptor, EP2 subtype | Prostaglandin E2 | Prostaglandin E2 receptor EP2 subtype | Prostanoid EP2 receptor | Ptger2 | Ptgerep2
Type:
G-protein coupled receptor
Mol. Mass.:
40495.26
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
362
Sequence:
MDNFLNDSKLMEDCKSRQWLLSGESPAISSVMFSAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESHACTYFAFTMTFFSLATMLMLFAMALERYLSIGYPYFYRRHLSRRGGLAVLPVIYGASLLFCSLPLLNYGEYVQYCPGTWCFIRHGRTAYLQLYATMLLLLIVAVLACNISVILNLIRMHRRSRRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAICSLPFTIFAYMDETSSLKEKWDLRALRFLSVNSIIDPWVFAILRPPVLRLMRSVLCCRTSLRTQEAQQTSCSTQSSASKQTDLCGQL
  
Inhibitor
Name:
BDBM50350349
Synonyms:
CHEMBL1813115
Type:
Small organic molecule
Emp. Form.:
C28H26N2O5
Mol. Mass.:
470.5164
SMILES:
CN1C[C@@H](COc2ccc(cc2)C(=O)n2c(C)c(CC(O)=O)c3ccccc23)Oc2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: