Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50351385
Substrate
n/a
Meas. Tech.
ChEMBL_764455 (CHEMBL1821007)
IC50
22±n/a nM
Citation
 Saito, T; Obitsu, T; Kondo, T; Matsui, T; Nagao, Y; Kusumi, K; Matsumura, N; Ueno, S; Kishi, A; Katsumata, S; Kagamiishi, Y; Nakai, H; Toda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem 19:5432-45 (2011) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50351385
Synonyms:
CHEMBL1819075
Type:
Small organic molecule
Emp. Form.:
C24H32N4O
Mol. Mass.:
392.5371
SMILES:
CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1cc(C)c(OC)cc1C |(-1.74,-12.88,;-3.09,-13.63,;-3.12,-15.17,;-1.8,-15.96,;-.45,-15.22,;-4.47,-15.91,;-4.5,-17.45,;-5.85,-18.2,;-7.31,-17.69,;-8.24,-18.93,;-7.35,-20.19,;-5.88,-19.74,;-4.56,-20.54,;-3.2,-19.78,;-1.74,-20.27,;-.83,-19.04,;.71,-19.06,;-1.71,-17.79,;-3.18,-18.24,;-1.28,-21.74,;-2.33,-22.87,;-1.87,-24.34,;-2.92,-25.47,;-.37,-24.68,;.09,-26.15,;-.95,-27.28,;.68,-23.54,;.21,-22.07,;1.25,-20.94,)|
Structure:
Search PDB for entries with ligand similarity: