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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50351393
Substrate
n/a
Meas. Tech.
ChEMBL_764455 (CHEMBL1821007)
IC50
3±n/a nM
Citation
 Saito, T; Obitsu, T; Kondo, T; Matsui, T; Nagao, Y; Kusumi, K; Matsumura, N; Ueno, S; Kishi, A; Katsumata, S; Kagamiishi, Y; Nakai, H; Toda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem 19:5432-45 (2011) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50351393
Synonyms:
CHEMBL1819083
Type:
Small organic molecule
Emp. Form.:
C22H25ClF2N4O
Mol. Mass.:
434.91
SMILES:
CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1ccc(OC(F)F)cc1Cl |(46.52,-30.65,;45.17,-31.39,;45.14,-32.93,;46.46,-33.73,;47.81,-32.98,;43.79,-33.68,;43.76,-35.22,;42.41,-35.96,;40.95,-35.46,;40.02,-36.69,;40.91,-37.95,;42.38,-37.51,;43.7,-38.3,;45.06,-37.54,;46.52,-38.04,;47.44,-36.8,;48.98,-36.82,;46.55,-35.55,;45.08,-36.01,;46.98,-39.51,;45.93,-40.64,;46.39,-42.1,;47.89,-42.44,;48.35,-43.91,;47.31,-45.05,;47.77,-46.52,;45.81,-44.71,;48.94,-41.3,;48.47,-39.84,;49.51,-38.7,)|
Structure:
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