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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50351397
Substrate
n/a
Meas. Tech.
ChEMBL_764455 (CHEMBL1821007)
IC50
22±n/a nM
Citation
 Saito, T; Obitsu, T; Kondo, T; Matsui, T; Nagao, Y; Kusumi, K; Matsumura, N; Ueno, S; Kishi, A; Katsumata, S; Kagamiishi, Y; Nakai, H; Toda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem 19:5432-45 (2011) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50351397
Synonyms:
CHEMBL1819087
Type:
Small organic molecule
Emp. Form.:
C21H25ClN4O2
Mol. Mass.:
400.902
SMILES:
CCC(CC)Nc1c2COCc2nc2c(c(C)nn12)-c1ccc(OC)cc1Cl |(-.65,-11.56,;-2,-12.31,;-2.02,-13.85,;-.71,-14.64,;.64,-13.9,;-3.37,-14.59,;-3.4,-16.13,;-4.75,-16.88,;-6.21,-16.37,;-7.14,-17.6,;-6.26,-18.87,;-4.78,-18.42,;-3.4,-19.27,;-2.1,-18.46,;-.65,-18.95,;.27,-17.72,;1.81,-17.74,;-.62,-16.46,;-2.08,-16.92,;-.19,-20.42,;-1.23,-21.55,;-.78,-23.02,;.73,-23.36,;1.19,-24.83,;.15,-25.96,;1.77,-22.22,;1.31,-20.75,;2.35,-19.61,)|
Structure:
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