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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50351386
Substrate
n/a
Meas. Tech.
ChEMBL_764454 (CHEMBL1821006)
EC50
80±n/a nM
Citation
 Saito, T; Obitsu, T; Kondo, T; Matsui, T; Nagao, Y; Kusumi, K; Matsumura, N; Ueno, S; Kishi, A; Katsumata, S; Kagamiishi, Y; Nakai, H; Toda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem 19:5432-45 (2011) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50351386
Synonyms:
CHEMBL1819076
Type:
Small organic molecule
Emp. Form.:
C24H32N4O
Mol. Mass.:
392.5371
SMILES:
CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1c(C)cc(OC)cc1C |(11.43,-13.22,;10.08,-13.96,;10.05,-15.5,;11.37,-16.3,;12.72,-15.55,;8.71,-16.25,;8.68,-17.79,;7.33,-18.53,;5.87,-18.03,;4.94,-19.26,;5.82,-20.52,;7.3,-20.08,;8.62,-20.87,;9.98,-20.11,;11.43,-20.61,;12.35,-19.37,;13.89,-19.39,;11.46,-18.12,;10,-18.58,;11.89,-22.08,;13.39,-22.41,;14.43,-21.27,;13.85,-23.87,;12.81,-25.01,;13.27,-26.48,;12.22,-27.62,;11.3,-24.67,;10.85,-23.21,;9.34,-22.87,)|
Structure:
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