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Target
Prostaglandin D2 receptor 2
Ligand
BDBM50356677
Substrate
n/a
Meas. Tech.
ChEMBL_785712 (CHEMBL1920640)
Ki
0.370000±n/a nM
Citation
 Crosignani, S; Prêtre, A; Jorand-Lebrun, C; Fraboulet, G; Seenisamy, J; Augustine, JK; Missotten, M; Humbert, Y; Cleva, C; Abla, N; Daff, H; Schott, O; Schneider, M; Burgat-Charvillon, F; Rivron, D; Hamernig, I; Arrighi, JF; Gaudet, M; Zimmerli, SC; Juillard, P; Johnson, Z Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J Med Chem 54:7299-317 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD294 antigen | Crth2 | G protein-coupled receptor 44 | Gpr44 | PD2R2_MOUSE | Ptgdr2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42975.89
Organism:
Mus musculus (mouse)
Description:
Human embryonic kidney (HEK) 293(EBNA) cells were transfected with mouse CRTH2.
Residue:
382
Sequence:
MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
  
Inhibitor
Name:
BDBM50356677
Synonyms:
CHEMBL1917592
Type:
Small organic molecule
Emp. Form.:
C19H16ClFO5S
Mol. Mass.:
410.844
SMILES:
CCCS(=O)(=O)c1ccc(F)c(c1)C#Cc1cc(Cl)ccc1OCC(O)=O
Structure:
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