Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50357587
Substrate
n/a
Meas. Tech.
ChEMBL_788221 (CHEMBL1919423)
IC50
1±n/a nM
Citation
 Pierre, FStefan, ENédellec, ASChevrel, MCRegan, CFSiddiqui-Jain, AMacalino, DStreiner, NDrygin, DHaddach, MO'Brien, SEAnderes, KRyckman, DM 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett 21:6687-92 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Human
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50357587
Synonyms:
CHEMBL1915438
Type:
Small organic molecule
Emp. Form.:
C20H13ClN6
Mol. Mass.:
372.81
SMILES:
Clc1ccccc1Nc1nc2c(cccc2c2cnccc12)-c1nnc[nH]1
Structure:
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