Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Ligand
BDBM21447
Substrate
n/a
Meas. Tech.
ChEMBL_785797 (CHEMBL1920920)
Kd
>1000±n/a nM
Citation
Goreshnik, I; Brock, AM; Maly, DJ Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL. Bioorg Med Chem Lett 21:4951-5 (2011) [PubMed] Article More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Synonyms:
Mcl-1 | Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl1
Type:
Developmental protein
Mol. Mass.:
35215.08
Organism:
Mouse
Description:
n/a
Residue:
331
Sequence:
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Inhibitor
Name:
BDBM21447
Synonyms:
4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]benzamide | ABT-737 | CHEMBL376408 | N-Benylpiperazine derivative, 2 | US9125913, ABT-737 | US11760752, Compound ABT-737
Type:
Small organic molecule
Emp. Form.:
C42H45ClN6O5S2
Mol. Mass.:
812.26
SMILES:
CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 |r|
Structure:
