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Target
Galanin receptor type 2
Ligand
BDBM50358677
Substrate
n/a
Meas. Tech.
ChEMBL_789439 (CHEMBL1924415)
IC50
330±n/a nM
Citation
 Sagi, VN; Liu, T; Lu, X; Bartfai, T; Roberts, E Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2. Bioorg Med Chem Lett 21:7210-5 (2011) [PubMed]  Article 
Target
Name:
Galanin receptor type 2
Synonyms:
GALNR2 | GALR2 | GALR2_HUMAN | Galanin R2 | Galanin receptor 2 | Galanin receptor type 2 | Galanin receptor type 2 (GAL2-R) (GALR2).
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41724.40
Organism:
Homo sapiens (Human)
Description:
Galanin R2 GALR2 HUMAN::O43603
Residue:
387
Sequence:
MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
  
Inhibitor
Name:
BDBM50358677
Synonyms:
CHEMBL1922007
Type:
Small organic molecule
Emp. Form.:
C23H24F3N5O2
Mol. Mass.:
459.4642
SMILES:
COc1ccc(Nc2nc(Nc3ccc(OC(F)(F)F)cc3)cc(n2)N2CCCCC2)cc1
Structure:
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