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Target
Histamine H4 receptor
Ligand
BDBM50356885
Substrate
n/a
Meas. Tech.
ChEMBL_798257 (CHEMBL1943644)
Ki
27±n/a nM
Citation
 Lane, CA; Hay, D; Mowbray, CE; Paradowski, M; Selby, MD; Swain, NA; Williams, DH Synthesis of novel histamine H4 receptor antagonists. Bioorg Med Chem Lett 22:1156-9 (2012) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50356885
Synonyms:
CHEMBL1915345
Type:
Small organic molecule
Emp. Form.:
C16H18ClN3O
Mol. Mass.:
303.787
SMILES:
CN1C[C@H]2CN(C[C@H]2C1)C(=O)c1cc2cc(Cl)ccc2[nH]1 |r|
Structure:
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