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Target
Delta-type opioid receptor
Ligand
BDBM50362301
Substrate
n/a
Meas. Tech.
ChEMBL_797688 (CHEMBL1943908)
IC50
0.260000±n/a nM
Citation
 McCauley, JP; Dantzman, CL; King, MM; Ernst, GE; Wang, X; Brush, K; Palmer, WE; Frietze, W; Andisik, DW; Hoesch, V; Doring, K; Hulsizer, J; Bui, KH; Liu, J; Hudzik, TJ; Wesolowski, SS Multiparameter exploration of piperazine derivatives asd-opioid receptor agonists for CNS indications. Bioorg Med Chem Lett 22:1169-73 (2012) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50362301
Synonyms:
CHEMBL1939749
Type:
Small organic molecule
Emp. Form.:
C29H38N6O3
Mol. Mass.:
518.6504
SMILES:
CCOC(=O)Nc1cccc(c1)[C@H](N1CCN(Cc2[nH]cnc2C)CC1)c1ccc(cc1)C(=O)N(C)CC |r|
Structure:
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