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Target
B1 bradykinin receptor
Ligand
BDBM50362365
Substrate
n/a
Meas. Tech.
ChEMBL_797692 (CHEMBL1943912)
IC50
0.28±n/a nM
Citation
 Qian, W; Chen, JJ; Human, J; Aya, T; Zhu, J; Biswas, K; Peterkin, T; Hungate, RW; Arik, L; Johnson, E; Kumar, G; Joseph, S; Jona, J; Guo, HX; Wu, Z Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency. Bioorg Med Chem Lett 22:1061-7 (2012) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50362365
Synonyms:
CHEMBL1939756
Type:
Small organic molecule
Emp. Form.:
C24H28N4O4S
Mol. Mass.:
468.569
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1C=CNC(=O)[C@H]1CC(=O)N[C@@H]1CCCc2cc(CN)ccc12 |r,c:12|
Structure:
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