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Target
Translocator protein
Ligand
BDBM50363514
Substrate
n/a
Meas. Tech.
ChEMBL_801514 (CHEMBL1948441)
Ki
0.38±n/a nM
Citation
 Wadsworth, H; Jones, PA; Chau, WF; Durrant, C; Fouladi, N; Passmore, J; O'Shea, D; Wynn, D; Morisson-Iveson, V; Ewan, A; Thaning, M; Mantzilas, D; Gausemel, I; Khan, I; Black, A; Avory, M; Trigg, W [¹¿?¿F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO). Bioorg Med Chem Lett 22:1308-13 (2012) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50363514
Synonyms:
CHEMBL1946091
Type:
Small organic molecule
Emp. Form.:
C20H27FN2O
Mol. Mass.:
330.4396
SMILES:
CCCN(CC)C(=O)C1CCCc2c1c1ccccc1n2CCF
Structure:
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