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Target
Prostaglandin D2 receptor
Ligand
BDBM50363924
Substrate
n/a
Meas. Tech.
ChEMBL_805477 (CHEMBL1955370)
IC50
9±n/a nM
Citation
 Liu, J; Li, AR; Wang, Y; Johnson, MG; Su, Y; Shen, W; Wang, X; Lively, S; Brown, M; Lai, S; Gonzalez Lopez De Turiso, F; Xu, Q; Van Lengerich, B; Schmitt, M; Fu, Z; Sun, Y; Lawlis, S; Seitz, L; Danao, J; Wait, J; Ye, Q; Tang, HL; Grillo, M; Collins, TL; Sullivan, TJ; Medina, JC Discovery of AMG 853, a CRTH2 and DP Dual Antagonist. ACS Med Chem Lett 2:326-330 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor
Synonyms:
PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor
Type:
Enzyme
Mol. Mass.:
40288.87
Organism:
Homo sapiens (Human)
Description:
Q13258
Residue:
359
Sequence:
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
  
Inhibitor
Name:
BDBM50363924
Synonyms:
CHEMBL1951571
Type:
Small organic molecule
Emp. Form.:
C26H20ClF5N2O6S
Mol. Mass.:
618.957
SMILES:
OC(=O)Cc1cc(F)c(Oc2ccc(cc2NS(=O)(=O)c2ccc(cc2Cl)C(F)(F)F)C(=O)NC2CCC2)cc1F
Structure:
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