Reaction Details Report a problem with these data
Target
Cholesteryl ester transfer protein
Ligand
BDBM50312718
Substrate
n/a
Meas. Tech.
ChEMBL_802754 (CHEMBL1953400)
IC50
13±n/a nM
Citation
 Thompson, CF; Ali, A; Quraishi, N; Lu, Z; Hammond, ML; Sinclair, PJ; Anderson, MS; Eveland, SS; Guo, Q; Hyland, SA; Milot, DP; Sparrow, CP; Wright, SD Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein. ACS Med Chem Lett 2:424-427 (2011) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50312718
Synonyms:
CHEMBL479527 | torcetrapib
Type:
Small organic molecule
Emp. Form.:
C26H25F9N2O4
Mol. Mass.:
600.4733
SMILES:
CCOC(=O)N1[C@H](CC)C[C@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)OC)c2cc(ccc12)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: