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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50364676
Substrate
n/a
Meas. Tech.
ChEMBL_802881 (CHEMBL1953699)
IC50
0.44±n/a nM
Citation
 Shen, HC; Ding, FX; Jiang, J; Verras, A; Chabin, RM; Xu, S; Tong, X; Chen, Q; Xie, D; Lassman, ME; Bhatt, UR; Garcia-Calvo, MM; Geissler, W; Shen, Z; Murphy, BA; Gorski, JN; Wiltsie, J; SinhaRoy, R; Hale, JJ; Pinto, S; Shen, DM Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorg Med Chem Lett 22:1550-6 (2012) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Lysosomal carboxypeptidase C | Angiotensinase C | Proline carboxypeptidase | Prolylcarboxypeptidase | PCP_HUMAN | PRCP | PCP | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Human
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM50364676
Synonyms:
CHEMBL1951465 | US8785634, 1
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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