Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50365232
Substrate
n/a
Meas. Tech.
ChEMBL_808186 (CHEMBL1961098)
IC50
>100000±n/a nM
Citation
 Coteron, JMMarco, MEsquivias, JDeng, XWhite, KLWhite, JKoltun, MEl Mazouni, FKokkonda, SKatneni, KBhamidipati, RShackleford, DMAngulo-Barturen, IFerrer, SBJiménez-Díaz, MBGamo, FJGoldsmith, EJCharman, WNBathurst, IFloyd, DMatthews, DBurrows, JNRathod, PKCharman, SAPhillips, MA Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem 54:5540-61 (2011) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50365232
Synonyms:
CHEMBL1956283 | US9238653, Table 5, Compound 54
Type:
Small organic molecule
Emp. Form.:
C14H12ClF2N5
Mol. Mass.:
323.728
SMILES:
Cc1cc(Nc2ccc(Cl)cc2)n2nc(nc2n1)C(C)(F)F
Structure:
Search PDB for entries with ligand similarity: