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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50156547
Substrate
n/a
Meas. Tech.
ChEMBL_808318 (CHEMBL1960894)
EC50
3.1±n/a nM
Citation
 Kambe, T; Maruyama, T; Nakai, Y; Yoshida, H; Oida, H; Maruyama, T; Abe, N; Nishiura, A; Nakai, H; Toda, M Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists. Bioorg Med Chem 20:2235-51 (2012) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_RAT | Ptger4 | Prostanoid EP4 receptor
Type:
PROTEIN
Mol. Mass.:
53381.95
Organism:
Rat
Description:
ChEMBL_1290039
Residue:
488
Sequence:
MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
  
Inhibitor
Name:
BDBM50156547
Synonyms:
4-(2-((R)-2-((S)-3-hydroxyoct-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoate | 4-(2-((R)-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid | CHEMBL222715
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O |r|
Structure:
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