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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM35847
Substrate
n/a
Meas. Tech.
ChEMBL_808318 (CHEMBL1960894)
EC50
3.5±n/a nM
Citation
 Kambe, T; Maruyama, T; Nakai, Y; Yoshida, H; Oida, H; Maruyama, T; Abe, N; Nishiura, A; Nakai, H; Toda, M Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists. Bioorg Med Chem 20:2235-51 (2012) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_RAT | Ptger4 | Prostanoid EP4 receptor
Type:
PROTEIN
Mol. Mass.:
53381.95
Organism:
Rat
Description:
ChEMBL_1290039
Residue:
488
Sequence:
MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
  
Inhibitor
Name:
BDBM35847
Synonyms:
DINOPROSTONE | [3H]Prostaglandin E2 | prostaglandin E2 | CHEMBL548 | (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid | [3H]Dinoprostone | (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid | PGE2 | (15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid | [3H]PGE2
Type:
radiolabeled ligand
Emp. Form.:
C20H32O5
Mol. Mass.:
352.22
SMILES:
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Structure:
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