Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50290232
Substrate
n/a
Meas. Tech.
ChEBML_58772
Ki
3.2±n/a nM
Citation
 Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7:2403-2408 (1997)    Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50290232
Synonyms:
CHEMBL309501 | Thiophene-2-carboxylic acid {4-[2-(4-o-tolyl-piperazin-1-yl)-ethyl]-cyclohexyl}-amide
Type:
Small organic molecule
Emp. Form.:
C24H33N3OS
Mol. Mass.:
411.603
SMILES:
Cc1ccccc1N1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)c2cccs2)CC1 |wU:13.13,wD:16.20,(14.33,-.78,;15.14,-2.08,;16.67,-2.05,;17.48,-3.37,;16.74,-4.72,;15.2,-4.76,;14.4,-3.44,;12.86,-3.46,;12.13,-4.81,;10.59,-4.84,;9.78,-3.53,;8.24,-3.55,;7.49,-4.9,;5.95,-4.91,;5.16,-6.24,;3.62,-6.24,;2.87,-4.91,;3.62,-3.58,;5.16,-3.58,;1.33,-4.92,;.56,-6.25,;-.98,-6.26,;1.33,-7.58,;2.85,-7.66,;2.71,-10.32,;1.17,-10.23,;.47,-8.87,;10.53,-2.18,;12.07,-2.15,)|
Structure:
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