Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50290225
Substrate
n/a
Meas. Tech.
ChEBML_58772
Ki
0.600000±n/a nM
Citation
 Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7:2403-2408 (1997)    Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50290225
Synonyms:
CHEMBL78950 | Thiophene-2-carboxylic acid (4-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide
Type:
Small organic molecule
Emp. Form.:
C24H33N3O2S
Mol. Mass.:
427.603
SMILES:
COc1ccccc1N1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)c2cccs2)CC1 |wU:14.14,wD:17.21,(16.01,-4.6,;17.55,-4.56,;18.35,-5.88,;19.89,-5.84,;20.69,-7.16,;19.95,-8.52,;18.41,-8.55,;17.61,-7.22,;16.07,-7.26,;15.34,-8.59,;13.8,-8.62,;13,-7.31,;11.46,-7.35,;10.69,-8.69,;9.15,-8.69,;8.38,-10.02,;6.84,-10.03,;6.07,-8.7,;6.84,-7.37,;8.38,-7.36,;4.53,-8.71,;3.76,-10.04,;2.22,-10.04,;4.53,-11.37,;6.07,-11.46,;5.93,-14.1,;4.39,-14.02,;3.69,-12.65,;13.75,-5.97,;15.29,-5.93,)|
Structure:
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