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Target
Prothrombin
Ligand
BDBM50079633
Substrate
n/a
Meas. Tech.
ChEBML_207983
IC50
600±n/a nM
Citation
 Li, M; Lin, Z; Johnson, ME Structure-based design and synthesis of novel thrombin inhibitors based on phosphinic peptide mimetics. Bioorg Med Chem Lett 9:1957-62 (1999) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50079633
Synonyms:
CHEMBL294418 | [(S)-1-((R)-2-Amino-3-naphthalen-2-yl-propionylamino)-2-(4-carbamimidoyl-phenyl)-ethyl]-phenyl-phosphinium
Type:
Small organic molecule
Emp. Form.:
C28H29N4O3P
Mol. Mass.:
500.5286
SMILES:
N[C@H](Cc1ccc2ccccc2c1)C(=O)NC(Cc1ccc(cc1)C(N)=[NH2+])=P(O)([O-])c1ccccc1
Structure:
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