Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50101362
Substrate
n/a
Meas. Tech.
ChEBML_45271
Ki
23±n/a nM
Citation
 Mincione, F; Starnotti, M; Menabuoni, L; Scozzafava, A; Casini, A; Supuran, CT Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties. Bioorg Med Chem Lett 11:1787-91 (2001) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
  
Inhibitor
Name:
BDBM50101362
Synonyms:
(S)-2-[(S)-3-(3H-Imidazol-4-yl)-2-(4-sulfamoyl-benzoylamino)-propionylamino]-3-phenyl-propionic acid | CHEMBL298110
Type:
Small organic molecule
Emp. Form.:
C22H23N5O6S
Mol. Mass.:
485.513
SMILES:
NS(=O)(=O)c1ccc(cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: